Exploration of liver cancer genomes.

doi:10.1038/nrgastro.2014.6

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Article

Exploration of liver cancer genomes.

Nature reviews. Gastroenterology & hepatology - 1 Jun 2014

Shibata Tatsuhiro, Aburatani Hiroyuki

Abstract excerpt

Liver cancer is the third leading cause of cancer-related death worldwide. Advances in sequencing technologies have enabled the examination of liver cancer genomes at high resolution; somatic mutations, structural alterations, HBV integration, RNA editing and retrotransposon changes have been comprehensively identified. Furthermore, integrated analyses of trans-omics data (genome, transcriptome and methylome...

Topics

Carcinoma, Hepatocellular
DNA Methylation
Genome, Human
Genome-Wide Association Study
Hepatitis B virus
Humans
Liver Neoplasms
Mutation
Retroelements

Source

Open in PubMed

Identifiers

PMID: 24473361
DOI: 10.1038/nrgastro.2014.6

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