Article
Understanding the tumor immune microenvironment (TIME) for effective therapy.
Nature medicine - 1 May 2018
Binnewies Mikhail, Roberts Edward W, Kersten Kelly, Chan Vincent, Fearon Douglas F, Merad Miriam, Coussens Lisa M, Gabrilovich Dmitry I, Ostrand-Rosenberg Suzanne, Hedrick Catherine C, Vonderheide Robert H, Pittet Mikael J, Jain Rakesh K, Zou Weiping, Howcroft T Kevin, Woodhouse Elisa C, Weinberg Robert A, Krummel Matthew F
Abstract excerpt
The clinical successes in immunotherapy have been both astounding and at the same time unsatisfactory. Countless patients with varied tumor types have seen pronounced clinical response with immunotherapeutic intervention; however, many more patients have experienced minimal or no clinical benefit when provided the same treatment. As technology has advanced, so has the understanding of the complexity and diversity...
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