Article
Immune Contexture, Immunoscore, and Malignant Cell Molecular Subgroups for Prognostic and Theranostic Classifications of Cancers.
Advances in immunology - 1 Jan 2016
Becht Etienne, Giraldo Nicolas A, Germain Claire, de Reyniès Aurélien, Laurent-Puig Pierre, Zucman-Rossi Jessica, Dieu-Nosjean Marie-Caroline, Sautès-Fridman Catherine, Fridman Wolf H
Abstract excerpt
The outcome of tumors results from genetic and epigenetic modifications of the transformed cells and also from the interactions of the malignant cells with their tumor microenvironment (TME), which includes immune and inflammatory cells. For a given cancer type, the composition of the immunological TME is not homogeneous. Heterogeneity is found between different cancer types and also between tumors from patients...
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