Article
Bioinformatics Approaches to Profile the Tumor Microenvironment for Immunotherapeutic Discovery.
Current pharmaceutical design - 1 Jan 2017
Clancy Trevor, Dannenfelser Ruth, Troyanskaya Olga, Malmberg Karl Johan, Hovig Eivind, Kristensen Vessela
Abstract excerpt
In the microenvironment of a malignancy, tumor cells do not exist in isolation, but rather in a diverse ecosystem consisting not only of heterogeneous tumor-cell clones, but also normal cell types such as fibroblasts, vasculature, and an extensive pool of immune cells at numerous possible stages of activation and differentiation. This results in a complex interplay of diverse cellular signaling systems, where the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.