Article
Bioinformatics Approaches to Profile the Tumor Microenvironment for Immunotherapeutic Discovery.
Current pharmaceutical design - 1 Jan 2017
Clancy Trevor, Dannenfelser Ruth, Troyanskaya Olga, Malmberg Karl Johan, Hovig Eivind, Kristensen Vessela
Abstract excerpt
In the microenvironment of a malignancy, tumor cells do not exist in isolation, but rather in a diverse ecosystem consisting not only of heterogeneous tumor-cell clones, but also normal cell types such as fibroblasts, vasculature, and an extensive pool of immune cells at numerous possible stages of activation and differentiation. This results in a complex interplay of diverse cellular signaling systems, where the...
Topics
- Animals
- Antineoplastic Agents, Immunological
- Computational Biology
- Computer Simulation
- Gene Expression Regulation, Neoplastic
- Humans
- Immunotherapy
- Neoplasms
- Phenotype
- Tumor Microenvironment