Article

The Prognostic Role of <i>IRS2</i> in Breast Cancer: Interactions with Glucose Metabolism and Menopausal Status

2025-07-15

Abstract excerpt

The Insulin Receptor Substrate 2 ( IRS2 ) gene encodes an adapter protein that transmits insulin signals to regulate various cell functions, including metabolism, growth, and survival. Dysregulation of IRS2 activity is often associated with obesity and type 2 diabetes. Both conditions are strongly associated with a higher breast cancer risk. IRS2 is predominantly regulated in various tissues at the level of expres...

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Literature Corpus work: 116ff0ae-1485-5f4e-946e-6dd5b9386308
DOI: 10.1101/2025.07.14.25331512

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