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Article

Genome-Wide Somatic Copy Number Alterations and Mutations in High-Grade Pancreatic Intraepithelial Neoplasia.

The American journal of pathology - 1 Jul 2018

Hata Tatsuo, Suenaga Masaya, Marchionni Luigi, Macgregor-Das Anne, Yu Jun, Shindo Koji, Tamura Koji, Hruban Ralph H, Goggins Michael

Abstract excerpt

To obtain a better understanding of the genetic alterations of high-grade pancreatic intraepithelial neoplasia (HG-PanIN), we performed whole-genome copy number analysis by using single nucleotide polymorphism microarrays and targeted next-generation sequencing of 11 microdissected HG-PanIN and two low-grade PanIN lesions associated with HG-PanIN. HG-PanIN mutation profiles were compared with those of their...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29684357
DOI: 10.1016/j.ajpath.2018.03.012
PMCID: PMC6024190

Genes

SMAD4
CCNE1
KRAS
MYC

Provenance

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