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Article

Site-Specific Genomic Alterations in a Well-Differentiated Pancreatic Neuroendocrine Tumor With High-Grade Progression.

Pancreas - 1 Apr 2018

Martin David R, LaBauve Elisa, Pomo Joseph M, Chiu Vi K, Hanson Joshua A, Gullapalli Rama R

Abstract excerpt

The major categories of pancreatic neuroendocrine tumor (PanNET) are well-differentiated NET and poorly differentiated neuroendocrine carcinoma. Sequencing of these tumors has identified multiple important genes in the pathogenesis of PanNETs, such as DAXX/ATRX, MEN1, TP53, RB, and mTOR pathway genes. We identified a case of well-differentiated PanNET with high-grade progression with simultaneous low- and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29521944
DOI: 10.1097/MPA.0000000000001030
PMCID: PMC5884111

Genes

DAXX
MEN1
ATRX
PTEN
SMAD4

Provenance

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