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Phase 2a, randomized, double-blind, placebo-controlled, multicentre, parallel-group study of an H4 R-antagonist (JNJ-39758979) in adults with uncontrolled asthma.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Aug 2018

Kollmeier A P, Greenspan A, Xu X L, Silkoff P E, Barnathan E S, Loza M J, Jiang J, Zhou B, Chen B, Thurmond R L

Abstract excerpt

BACKGROUND: The effects of H4 R antagonists in preclinical asthma models support the study of antagonists of the H4 R in the treatment of asthma in humans. JNJ-39758979 is a potent and highly selective oral H4 R antagonist. OBJECTIVE: We sought to evaluate the safety and efficacy of the H4 R-antagonist JNJ-39758979 in adult patients with uncontrolled asthma. METHODS: One hundred and fifteen eligible patients were...

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Identifiers

PMID: 29682796
DOI: 10.1111/cea.13154

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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