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Article

Global genome diversity of the Leishmania donovani complex.

eLife - 25 Mar 2020

Franssen Susanne U, Durrant Caroline, Stark Olivia, Moser Bettina, Downing Tim, Imamura Hideo, Dujardin Jean-Claude, Sanders Mandy J, Mauricio Isabel, Miles Michael A, Schnur Lionel F, Jaffe Charles L, Nasereddin Abdelmajeed, Schallig Henk, Yeo Matthew, Bhattacharyya Tapan, Alam Mohammad Z, Berriman Matthew, Wirth Thierry, Schönian Gabriele, Cotton James A

Abstract excerpt

Protozoan parasites of the Leishmania donovani complex - L. donovani and L. infantum - cause the fatal disease visceral leishmaniasis. We present the first comprehensive genome-wide global study, with 151 cultured field isolates representing most of the geographical distribution. L. donovani isolates separated into five groups that largely coincide with geographical origin but vary greatly in diversity. In...

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Identifiers

PMID: 32209228
DOI: 10.7554/eLife.51243
PMCID: PMC7105377

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