Article
FoxO restricts growth and differentiation of cells with elevated TORC1 activity under nutrient restriction.
PLoS genetics - 1 Apr 2018
Nowak Katarzyna, Gupta Avantika, Stocker Hugo
Abstract excerpt
TORC1, a central regulator of cell survival, growth, and metabolism, is activated in a variety of cancers. Loss of the tumor suppressors PTEN and Tsc1/2 results in hyperactivation of TORC1. Tumors caused by the loss of PTEN, but not Tsc1/2, are often malignant and have been shown to be insensitive to nutrient restriction (NR). In Drosophila, loss of PTEN or Tsc1 results in hypertrophic overgrowth of epithelial...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.