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Article

Autophagy regulates tissue overgrowth in a context-dependent manner.

Oncogene - 1 Jun 2015

Pérez E, Das G, Bergmann A, Baehrecke E H

Abstract excerpt

Autophagy is a catabolic process that has been implicated both as a tumor suppressor and in tumor progression. Here, we investigate this dichotomy in cancer biology by studying the influence of altered autophagy in Drosophila models of tissue overgrowth. We find that the impact of altered autophagy depends on both genotype and cell type. As previously observed in mammals, decreased autophagy suppresses...

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Identifiers

PMID: 25174403
DOI: 10.1038/onc.2014.285
PMCID: PMC4345156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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