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Article

A Potential Role for Exosomal Translationally Controlled Tumor Protein Export in Vascular Remodeling in Pulmonary Arterial Hypertension.

American journal of respiratory cell and molecular biology - 1 Oct 2018

Ferrer Elisabet, Dunmore Benjamin J, Hassan Dhiya, Ormiston Mark L, Moore Stephen, Deighton John, Long Lu, Yang Xu Dong, Stewart Duncan J, Morrell Nicholas W

Abstract excerpt

Pulmonary arterial hypertension (PAH) is characterized by increased proliferation and resistance to apoptosis of pulmonary vascular cells. Increased expression of translationally controlled tumor protein (TCTP), a prosurvival and antiapoptotic mediator, has recently been demonstrated in patients with heritable PAH; however, its role in the pathobiology of PAH remains unclear. Silencing of TCTP in blood outgrowth...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29676587
DOI: 10.1165/rcmb.2017-0129OC
PMCID: PMC6178156

Genes

PAH
BMPR2

Provenance

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