Article
Extracellular vesicle cross-talk between pulmonary artery smooth muscle cells and endothelium during excessive TGF-β signalling: implications for PAH vascular remodelling.
Cell communication and signaling : CCS - 8 Nov 2019
de la Cuesta Fernando, Passalacqua Ilaria, Rodor Julie, Bhushan Raghu, Denby Laura, Baker Andrew H
Abstract excerpt
BACKGROUND: Excessive TGF-β signalling has been shown to underlie pulmonary hypertension (PAH). Human pulmonary artery smooth muscle cells (HPASMCs) can release extracellular vesicles (EVs) but their contents and significance have not yet been studied. Here, we aimed to analyse the contents and biological relevance of HPASMC-EVs and their transport to human pulmonary arterial endothelial cells (HPAECs), as well...
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