Article
Proteomic analysis implicates translationally controlled tumor protein as a novel mediator of occlusive vascular remodeling in pulmonary arterial hypertension.
Circulation - 27 May 2014
Lavoie Jessie R, Ormiston Mark L, Perez-Iratxeta Carol, Courtman David W, Jiang Baohua, Ferrer Elisabet, Caruso Paola, Southwood Mark, Foster William S, Morrell Nicholas W, Stewart Duncan J
Abstract excerpt
BACKGROUND: Pulmonary arterial hypertension (PAH) is a lethal disease characterized by excessive proliferation of pulmonary vascular endothelial cells (ECs). Hereditary PAH (HPAH) is often caused by mutations in the bone morphogenetic protein receptor type 2 gene (BMPR2). However, the mechanisms by which these mutations cause PAH remain unclear. Therefore, we screened for dysregulated proteins in blood-outgrowth...
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