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Article

Selection on the regulation of sympathetic nervous activity in humans and chimpanzees.

PLoS genetics - 1 Apr 2018

Lee Kang Seon, Chatterjee Paramita, Choi Eun-Young, Sung Min Kyung, Oh Jaeho, Won Hyejung, Park Seong-Min, Kim Youn-Jae, Yi Soojin V, Choi Jung Kyoon

Abstract excerpt

Adrenergic α2C receptor (ADRA2C) is an inhibitory modulator of the sympathetic nervous system. Knockout mice for this gene show physiological and behavioural alterations that are associated with the fight-or-flight response. There is evidence of positive selection on the regulation of this gene during chicken domestication. Here, we find that the neuronal expression of ADRA2C is lower in human and chimpanzee than...

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Identifiers

PMID: 29672586
DOI: 10.1371/journal.pgen.1007311
PMCID: PMC5908061

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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