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Article

Ancient and recent positive selection transformed opioid cis-regulation in humans.

PLoS biology - 1 Dec 2005

Rockman Matthew V, Hahn Matthew W, Soranzo Nicole, Zimprich Fritz, Goldstein David B, Wray Gregory A

Abstract excerpt

Changes in the cis-regulation of neural genes likely contributed to the evolution of our species' unique attributes, but evidence of a role for natural selection has been lacking. We found that positive natural selection altered the cis-regulation of human prodynorphin, the precursor molecule for...

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Identifiers

PMID: 16274263
DOI: 10.1371/journal.pbio.0030387
PMCID: PMC1283535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16274263-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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