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Article

Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception.

Gene - 6 Jun 2005

Yang Su, Liu Ying, Lin Alice A, Cavalli-Sforza L Luca, Zhao Zhongming, Su Bing

Abstract excerpt

MRGX2, a G-protein-coupled receptor, is specifically expressed in the sensory neurons of the human peripheral nervous system and involved in nociception. Here, we studied DNA polymorphism patterns and evolution of the MRGX2 gene in world-wide human populations and the representative nonhuman primate species. Our results demonstrated that MRGX2 had undergone adaptive changes in the path of human evolution, which...

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Share to Adaptation, Physiological
Share to Neurons, Afferent
Share to Nociceptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Structure, Secondary

Share to Receptors, G-Protein-Coupled

Share to Receptors, Neuropeptide

Source

Identifiers

PMID: 15862286
DOI: 10.1016/j.gene.2005.03.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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