Article
Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication.
Science (New York, N.Y.) - 29 Aug 2014
Carneiro Miguel, Rubin Carl-Johan, Di Palma Federica, Albert Frank W, Alföldi Jessica, Martinez Barrio Alvaro, Pielberg Gerli, Rafati Nima, Sayyab Shumaila, Turner-Maier Jason, Younis Shady, Afonso Sandra, Aken Bronwen, Alves Joel M, Barrell Daniel, Bolet Gerard, Boucher Samuel, Burbano Hernán A, Campos Rita, Chang Jean L, Duranthon Veronique, Fontanesi Luca, Garreau Hervé, Heiman David, Johnson Jeremy, Mage Rose G, Peng Ze, Queney Guillaume, Rogel-Gaillard Claire, Ruffier Magali, Searle Steve, Villafuerte Rafael, Xiong Anqi, Young Sarah, Forsberg-Nilsson Karin, Good Jeffrey M, Lander Eric S, Ferrand Nuno, Lindblad-Toh Kerstin, Andersson Leif
Abstract excerpt
The genetic changes underlying the initial steps of animal domestication are still poorly understood. We generated a high-quality reference genome for the rabbit and compared it to resequencing data from populations of wild and domestic rabbits. We identified more than 100 selective sweeps specific to domestic rabbits but only a relatively small number of fixed (or nearly fixed) single-nucleotide polymorphisms...
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