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Article

New use for CETSA: monitoring innate immune receptor stability via post-translational modification by OGT.

Journal of bioenergetics and biomembranes - 1 Jun 2018

Drake Walter R, Hou Ching-Wen, Zachara Natasha E, Grimes Catherine Leimkuhler

Abstract excerpt

O-GlcNAcylation is a dynamic and functionally diverse post-translational modification shown to affect thousands of proteins, including the innate immune receptor nucleotide-binding oligomerization domain-containing protein 2 (Nod2). Mutations of Nod2 (R702W, G908R and 1007 fs) are associated with Crohn's disease and have lower stabilities compared to wild type. Cycloheximide (CHX)-chase half-life assays have been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29671171
DOI: 10.1007/s10863-018-9754-z
PMCID: PMC6126917

Genes

OGT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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