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Motor deficits in neurofibromatosis type 1 mice: the role of the cerebellum

26 Feb 2011

Abstract excerpt

Neurofibromatosis type 1 (NF1) is an autosomal dominantly inherited disease, characterized by various neurocutaneous symptoms, cognitive impairments and problems in fine and gross motor performance. Although cognitive deficits in NF1 have been attributed to increased release of the inhibitory neurotransmitter γ-amino butyric acid (GABA) in the hippocampus, the origin of the motor deficits is unknown. Cerebellar...

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PMID: 21352477
DOI: 10.1111/j.1601-183x.2011.00685.x

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