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Article

Mutations in the pancreatic secretory enzymes CPA1 and CPB1 are associated with pancreatic cancer.

Proceedings of the National Academy of Sciences of the United States of America - 1 May 2018

Tamura Koji, Yu Jun, Hata Tatsuo, Suenaga Masaya, Shindo Koji, Abe Toshiya, MacGregor-Das Anne, Borges Michael, Wolfgang Christopher L, Weiss Matthew J, He Jin, Canto Marcia Irene, Petersen Gloria M, Gallinger Steven, Syngal Sapna, Brand Randall E, Rustgi Anil, Olson Sara H, Stoffel Elena, Cote Michele L, Zogopoulos George, Potash James B, Goes Fernando S, McCombie Richard W, Zandi Peter P, Pirooznia Mehdi, Kramer Melissa, Parla Jennifer, Eshleman James R, Roberts Nicholas J, Hruban Ralph H, Klein Alison Patricia, Goggins Michael

Abstract excerpt

To evaluate whether germline variants in genes encoding pancreatic secretory enzymes contribute to pancreatic cancer susceptibility, we sequenced the coding regions of CPB1 and other genes encoding pancreatic secretory enzymes and known pancreatitis susceptibility genes (PRSS1, CPA1, CTRC, and SPINK1) in a hospital series of pancreatic cancer cases and controls. Variants in CPB1, CPA1 (encoding carboxypeptidase...

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Source

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Identifiers

PMID: 29669919
DOI: 10.1073/pnas.1720588115
PMCID: PMC5939087

Genes

CPB1
CPA1
CTRC
PRSS1
SPINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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