Article
Endoplasmic stress-inducing variants in CPB1 and CPA1 and risk of pancreatic cancer: A case-control study and meta-analysis.
International journal of cancer - 1 Apr 2022
Kawamoto Makoto, Kohi Shiro, Abe Toshiya, Dbouk Mohamad, Macgregor-Das Anne, Koi Chiho, Song Ki-Byung, Borges Michael, Sugimine Ryo, Laheru Daniel, Hruban Ralph H, Roberts Nicholas, Klein Alison P, Goggins Michael
Abstract excerpt
Gene variants that encode pancreatic enzymes with impaired secretion can induce pancreatic acinar endoplasmic reticulum (ER) stress, cellular injury and pancreatitis. The role of such variants in pancreatic cancer risk has received little attention. We compared the prevalence of ER stress-inducing variants in CPA1 and CPB1 in patients with pancreatic ductal adenocarcinoma (PDAC cases), enrolled in the National...
Topics
- Carboxypeptidase B
- Carboxypeptidases A
- Carcinoma, Pancreatic Ductal
- Case-Control Studies
- Endoplasmic Reticulum Stress
- Genetic Predisposition to Disease
- Genetic Variation
- Humans
- Pancreatic Neoplasms
- Risk