Article
Variants in pancreatic carboxypeptidase genes CPA2 and CPB1 are not associated with chronic pancreatitis.
American journal of physiology. Gastrointestinal and liver physiology - 15 Oct 2015
Nakano Eriko, Geisz Andrea, Masamune Atsushi, Niihori Tetsuya, Hamada Shin, Kume Kiyoshi, Kakuta Yoichi, Aoki Yoko, Matsubara Yoichi, Ebert Karolin, Ludwig Maren, Braun Markus, Groneberg David A, Shimosegawa Tooru, Sahin-Tóth Miklós, Witt Heiko
Abstract excerpt
Genetic alterations in the carboxypeptidase A1 gene (CPA1) are associated with early onset chronic pancreatitis (CP). Besides CPA1, there are two other human pancreatic carboxypeptidases (CPA2 and CPB1). Here we examined whether CPA2 and CPB1 alterations are associated with CP in Japan and Germany. All exons and flanking introns of CPA2 and CPB1 were sequenced in 477 Japanese patients with CP (234 alcoholic, 243...
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