Article
Phenotypic plasticity of mesenchymal stem cells is crucial for mesangial repair in a model of immunoglobulin light chain-associated mesangial damage.
Ultrastructural pathology - 1 Jan 2000
Herrera Guillermo A, Teng Jiamin, Zeng Chun, Xu Hongzhi, Liang Man, Alexander J Steven, Liu Bing, Boyer Chris, Turbat-Herrera Elba A
Abstract excerpt
Mesangiopathies produced by glomerulopathic monoclonal immunoglobulin light chains (GLCs) acting on the glomerular mesangium produce two characteristic lesions: AL-amyloidosis (AL-Am) and light chain deposition disease (LCDD). In both cases, the pathology is centered in the mesangium, where initial and progressive damage occurs. In AL-Am the mesangial matrix is destroyed and replaced by amyloid fibrils and in...
Topics
- Animals
- Cells, Cultured
- Disease Models, Animal
- Glomerular Mesangium
- Humans
- Immunoglobulin Light Chains
- Mesangial Cells
- Mesenchymal Stem Cells
- Mice
- Phenotype
- Rats
- Renal Insufficiency, Chronic