Article
Phenotypic plasticity of mesenchymal stem cells is crucial for mesangial repair in a model of immunoglobulin light chain-associated mesangial damage.
Ultrastructural pathology - 1 Jan 2000
Herrera Guillermo A, Teng Jiamin, Zeng Chun, Xu Hongzhi, Liang Man, Alexander J Steven, Liu Bing, Boyer Chris, Turbat-Herrera Elba A
Abstract excerpt
Mesangiopathies produced by glomerulopathic monoclonal immunoglobulin light chains (GLCs) acting on the glomerular mesangium produce two characteristic lesions: AL-amyloidosis (AL-Am) and light chain deposition disease (LCDD). In both cases, the pathology is centered in the mesangium, where initial and progressive damage occurs. In AL-Am the mesangial matrix is destroyed and replaced by amyloid fibrils and in...
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