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Article

An animal model of glomerular light-chain-associated amyloidogenesis depicts the crucial role of lysosomes.

Kidney international - 1 Oct 2014

Teng Jiamin, Turbat-Herrera Elba A, Herrera Guillermo A

Abstract excerpt

In vitro and ex vivo studies have elucidated the step-by-step process whereby some physicochemically abnormal light chains are processed by mesangial cells to form amyloid fibrils. Although crucial steps in the cascade of events have been determined, these findings have not been reproduced in vivo. This has led to some doubts as to the significance and clinical application of the information that has been...

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Identifiers

PMID: 24786709
DOI: 10.1038/ki.2014.122

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