Article
Renal amyloidosis: current views on pathogenesis and impact on diagnosis.
Contributions to nephrology - 1 Jan 2011
Herrera Guillermo A, Teng Jiamin, Turbat-Herrera Elba A
Abstract excerpt
The amyloidoses constitute a group of diseases in which misfolding of extracellular proteins plays a fundamental role. The aggregation of normally soluble proteins into insoluble unbranching fibrils is the basic underlying pathology in amyloidosis. The process of amyloid formation generates toxic insoluble (in saline) protein aggregates that are deposited in tissues in the form of β- pleated sheets of fibrillary...
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