Role of translational research advancing the understanding of the pathogenesis of light chain‐mediated glomerulopathies

Abstract excerpt

Glomerulopathic light chains engage in pathological interactions with mesangial cells resulting in alterations in glomerular homeostasis. The crucial pathological events are centered in the mesangium and, therefore, research dealing with pathogenesis of these disorders is focused on this glomerular compartment. Particular physicochemical characteristics of these light chains are responsible for their ability to...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Amyloidosis: Diagnosis, Treatment, Outcomes
• Share to Chronic Kidney Disease and Diabetes
• Share to Renal Diseases and Glomerulopathies