Article
Human mesenchymal stem cells alter macrophage phenotype and promote regeneration via homing to the kidney following ischemia-reperfusion injury.
American journal of physiology. Renal physiology - 15 May 2014
Wise Andrea F, Williams Timothy M, Kiewiet Mensiena B G, Payne Natalie L, Siatskas Christopher, Samuel Chrishan S, Ricardo Sharon D
Abstract excerpt
Mesenchymal stem cells (MSCs) ameliorate injury and accelerate repair in many organs, including the kidney, although the reparative mechanisms and interaction with macrophages have not been elucidated. This study investigated the reparative potential of human bone marrow-derived MSCs and traced their homing patterns following administration to mice with ischemia-reperfusion (IR) injury using whole body...
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