Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Skin cells prefer a slower calcium pump.

The Journal of biological chemistry - 16 Mar 2018

Robia Seth L, Young Howard S

Abstract excerpt

Naturally occurring mutations of a calcium ion transporter can cause a skin condition known as Darier's disease. In this issue of JBC, Mikkelsen et al. describe a particularly interesting Darier's mutation that alters calcium transport by disrupting a kinetic braking mechanism that is unique to the SERCA2b calcium pump isoform. The study provides new insight into the intrinsic regulation of this transporter and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium
Share to Calcium Signaling
Share to Darier Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kinetics

Share to Mutation

Share to Protein Conformation

Share to Sarcoplasmic Reticulum Calcium-Transporting ATPases

Source

Open in PubMed Open full text

Identifiers

PMID: 29667928
DOI: 10.1074/jbc.H118.002088
PMCID: PMC5857981

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Skin cells prefer a slower calcium pump.PMID 29667928Read ↗

Darier disease: a guide to the physician.Semantic proximity Read ↗

Calcium pumps and keratinocytes: lessons from Darier's disease and Hailey-Hailey disease.Semantic proximity Read ↗

Darier's disease: from dyskeratosis to endoplasmic reticulum calcium ATPase deficiency.Semantic proximity Read ↗

Pumping the Breaks on Acantholytic Skin Disorders: Targeting Calcium Pumps, Desmosomes, and Downstream Signaling in Darier, Hailey-Hailey, and Grover Disease.Semantic proximity Read ↗

Distinct types of abnormality in kinetic properties of three Darier disease-causing sarco(endo)plasmic reticulum Ca2+-ATPase mutants that exhibit normal expression and high Ca2+ transport activity.Semantic proximity Read ↗

Darier's disease: a calcium-signaling perspective.Semantic proximity Read ↗

Calcium-ATPases: Gene disorders and dysregulation in cancer.Semantic proximity Read ↗

Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease.Semantic proximity Read ↗

Autosomal-dominant calcium ATPase disorders.Semantic proximity Read ↗

The focal nature of Darier's disease lesions: calcium pumps, stress, and mutation?Semantic proximity Read ↗

Darier disease--novel mutations in ATP2A2 and genotype-phenotype correlation.Semantic proximity Read ↗

SERCA2b loss of function drives pigmentation by inducing adaptive ER stress and enhancing mitochondrial calcium uptake: significance in pathological hyperpigmentation associated with Darier’s DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.