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Article

Determination of the Optimal Concentration of Valproic Acid in Patients with Epilepsy: A Population Pharmacokinetic-Pharmacodynamic Analysis.

PloS one - 1 Jan 2015

Nakashima Hiroo, Oniki Kentaro, Nishimura Miki, Ogusu Naoki, Shimomasuda Masatsugu, Ono Tatsumasa, Matsuda Kazuki, Yasui-Furukori Norio, Nakagawa Kazuko, Ishitsu Takateru, Saruwatari Junji

Abstract excerpt

Valproic acid (VPA) is one of the most widely prescribed antiepileptic drugs for the treatment of epileptic seizures. Although it is well known that the doses of VPA and its plasma concentrations are highly correlated, the plasma concentrations do not correlate well with the therapeutic effects of the VPA. In this study, we developed a population-based pharmacokinetic (PK)-pharmacodynamic (PD) model to determine...

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Identifiers

PMID: 26484865
DOI: 10.1371/journal.pone.0141266
PMCID: PMC4617862

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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