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Article

Clinical and prognostic features of patients with detailed RAS/BRAF-mutant colorectal cancer in Japan.

BMC cancer - 7 May 2021

Ikoma Tatsuki, Shimokawa Mototsugu, Kotaka Masahito, Matsumoto Toshihiko, Nagai Hiroki, Boku Shogen, Shibata Nobuhiro, Yasui Hisateru, Satake Hironaga

Abstract excerpt

BACKGROUND: RAS/BRAFV600E mutations are the most remarkable oncogenic driver mutations in colorectal cancer (CRC) and play an important role in treatment selection. No data are available regarding the clinical and prognostic features of patients with detailed RAS/BRAFV600E-mutant metastatic CRC (mCRC) in Japan. METHODS: A total of 152 chemotherapy-naïve patients with mCRC were included in this study between...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Colorectal Neoplasms
Female
GTP Phosphohydrolases
Humans
Male
Membrane Proteins
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Prognosis

Proto-Oncogene Proteins B-raf

Proto-Oncogene Proteins p21(ras)

Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 33962575
DOI: 10.1186/s12885-021-08271-z
PMCID: PMC8105976

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-33962575-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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