Article
Neutralizing antibodies in sera from macaques infected with chimeric simian-human immunodeficiency virus containing the envelope glycoproteins of either a laboratory-adapted variant or a primary isolate of human immunodeficiency virus type 1.
Journal of virology - 1 Apr 1998
Montefiori D C, Reimann K A, Wyand M S, Manson K, Lewis M G, Collman R G, Sodroski J G, Bolognesi D P, Letvin N L
Abstract excerpt
The magnitude and breadth of neutralizing antibodies raised in response to infection with chimeric simian-human immunodeficiency virus (SHIV) in rhesus macaques were evaluated. Infection with either SHIV-HXB2, SHIV-89.6, or SHIV-89.6PD raised high-titer neutralizing antibodies to the homologous S...
Topics
- Adaptation, Physiological
- Animals
- Cell Line, Transformed
- Gene Products, env
- Genetic Variation
- Glycoproteins
- HIV Antibodies
- HIV-1
- Humans
- Macaca mulatta
- Neutralization Tests
- Simian Immunodeficiency Virus