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Article

Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype.

Proceedings of the National Academy of Sciences of the United States of America - 29 Nov 2011

Blasius Amanda L, Dubin Adrienne E, Petrus Matt J, Lim Byung-Kwan, Narezkina Anna, Criado José R, Wills Derek N, Xia Yu, Moresco Eva Marie Y, Ehlers Cindy, Knowlton Kirk U, Patapoutian Ardem, Beutler Bruce

Abstract excerpt

The voltage-gated sodium channel Na(v)1.8 is known to function in the transmission of pain signals induced by cold, heat, and mechanical stimuli. Sequence variants of human Na(v)1.8 have been linked to altered cardiac conduction. We identified an allele of Scn10a encoding the α-subunit of Na(v)1....

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Identifiers

PMID: 22087007
DOI: 10.1073/pnas.1117020108
PMCID: PMC3228463

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22087007-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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