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Article

Tobacco Smoking-Associated Alterations in the Immune Microenvironment of Squamous Cell Carcinomas.

Journal of the National Cancer Institute - 1 Dec 2018

Desrichard Alexis, Kuo Fengshen, Chowell Diego, Lee Ken-Wing, Riaz Nadeem, Wong Richard J, Chan Timothy A, Morris Luc G T

Abstract excerpt

Background: Tobacco smoking creates DNA damage, inducing mutations and potentially altering the tumor immune microenvironment. These types of genetic and immune microenvironment alterations are critical factors known to affect tumor response to immunotherapy. Here we analyze the association between the mutational signature of tobacco smoking, tumor mutational load, and metrics of immune activity in squamous cell...

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Source

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Identifiers

PMID: 29659925
DOI: 10.1093/jnci/djy060
PMCID: PMC6292793

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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