Article
Association between the mutational smoking signature and the immune microenvironment in lung adenocarcinoma.
Lung cancer (Amsterdam, Netherlands) - 1 Sept 2020
Sato Kei, Mimaki Sachiyo, Yamashita Riu, Togashi Yosuke, Naito Tomoyuki, Udagawa Hibiki, Katsumata Shinya, Nakasone Shoko, Miyoshi Tomohiro, Tane Kenta, Aokage Keiju, Sugano Masato, Kojima Motohiro, Fujii Satoshi, Kuwata Takeshi, Ochiai Atsushi, Goto Koichi, Tsuboi Masahiro, Tsuchihara Katsuya, Ishii Genichiro
Abstract excerpt
OBJECTIVES: Mutational signatures associated with tobacco smoking (mutational smoking signatures: SS) are characterized mainly by C > A mutations. The aim of this study was to characterize the association between the tumor immune microenvironment and the SS in lung adenocarcinoma. METHODS: Lung adenocarcinomas surgically resected from 96 patients, for which whole exome sequencing data was available, were included...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.