Whole Exome and Transcriptome Analyses Integrated with Microenvironmental Immune Signatures of Lung Squamous Cell Carcinoma.

doi:10.1158/2326-6066.CIR-17-0453

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Article

Whole Exome and Transcriptome Analyses Integrated with Microenvironmental Immune Signatures of Lung Squamous Cell Carcinoma.

Cancer immunology research - 1 Jul 2018

Seo Jeong-Sun, Lee Ji Won, Kim Ahreum, Shin Jong-Yeon, Jung Yoo Jin, Lee Sae Bom, Kim Yoon Ho, Park Samina, Lee Hyun Joo, Park In-Kyu, Kang Chang-Hyun, Yun Ji-Young, Kim Jihye, Kim Young Tae

Abstract excerpt

The immune microenvironment in lung squamous cell carcinoma (LUSC) is not well understood, with interactions between the host immune system and the tumor, as well as the molecular pathogenesis of LUSC, awaiting better characterization. To date, no molecularly targeted agents have been developed for LUSC treatment. Identification of predictive and prognostic biomarkers for LUSC could help optimize therapy...

Topics

Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
Carcinoma, Squamous Cell
Cell Line, Tumor
Computational Biology
DNA Copy Number Variations
Female
Gene Expression Profiling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Lung Neoplasms

Male

Middle Aged

Mutation

Neoplasm Staging

Signal Transduction

Transcriptome

Source

Open in PubMed

Identifiers

PMID: 29720381
DOI: 10.1158/2326-6066.CIR-17-0453

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