Article

A zebrafish functional genomics model to investigate the role of human A20 variants <i>in vivo</i>

2020-02-25

Abstract excerpt

<h4>SUMMARY</h4> Germline loss-of-function variation in TNFAIP3 , encoding A20, has been implicated in a wide variety of autoinflammatory and autoimmune conditions, with acquired somatic missense mutations linked to cancer progression. Furthermore, human sequence data reveals that the A20 locus contains ~400 non-synonymous coding variants which are largely uncharacterised. The growing number of A20 coding varian...

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Literature Corpus work: 803d9c6a-c72e-58cb-a275-ef1e13153a4f
DOI: 10.1101/2020.02.23.961763

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