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Article

A zebrafish functional genomics model to investigate the role of human A20 variants in vivo.

Scientific reports - 5 Nov 2020

Cultrone Daniele, Zammit Nathan W, Self Eleanor, Postert Benno, Han Jeremy Z R, Bailey Jacqueline, Warren Joanna, Croucher David R, Kikuchi Kazu, Bogdanovic Ozren, Chtanova Tatyana, Hesselson Daniel, Grey Shane T

Abstract excerpt

Germline loss-of-function variation in TNFAIP3, encoding A20, has been implicated in a wide variety of autoinflammatory and autoimmune conditions, with acquired somatic missense mutations linked to cancer progression. Furthermore, human sequence data reveals that the A20 locus contains ~ 400 non-synonymous coding variants, which are largely uncharacterised. The growing number of A20 coding variants with unknown...

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Identifiers

PMID: 33154446
DOI: 10.1038/s41598-020-75917-6
PMCID: PMC7644770

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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