Interleukin-1 receptor-associated kinase-2 genetic variant rs708035 increases NF-κB activity through promoting TRAF6 ubiquitination.

doi:10.1074/jbc.M113.538009

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Article

Interleukin-1 receptor-associated kinase-2 genetic variant rs708035 increases NF-κB activity through promoting TRAF6 ubiquitination.

The Journal of biological chemistry - 2 May 2014

Zhang Weina, He Tao, Wang Qiong, Li Xin, Wei Jianming, Hou Xiaoqiang, Zhang Bin, Huang Lei, Wang Li

Abstract excerpt

The IL-1 receptor-associated kinases (IRAKs) are key regulators of Toll-like receptor (TLR)/IL-1 signaling, which are critical regulators of mammalian inflammation and innate immune response. Single nucleotide polymorphisms (SNPs) within the IRAK genes have been discovered recently. However, the functions of these IRAK SNPs remain largely unknown. Here, we found that the non-synonymous IRAK2 variant rs708035...

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Identifiers

PMID: 24662294
DOI: 10.1074/jbc.M113.538009
PMCID: PMC4007444

Genes

IRAK2
TRAF6

Variants

rs708035

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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