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Article

A recurrent truncating germline mutation in the BRIP1/FANCJ gene and susceptibility to prostate cancer.

British journal of cancer - 27 Jan 2009

Kote-Jarai Z, Jugurnauth S, Mulholland S, Leongamornlert D A, Guy M, Edwards S, Tymrakiewitcz M, O'Brien L, Hall A, Wilkinson R, Al Olama A A, Morrison J, Muir K, Neal D, Donovan J, Hamdy F, Easton D F, Eeles R

Abstract excerpt

Although prostate cancer (PrCa) is one of the most common cancers in men in Western countries, little is known about the inherited factors that influence PrCa risk. On the basis of the fact that BRIP1/FANCJ interacts with BRCA1 and functions as a regulator of DNA double-strand break repair pathways, and that germline mutations within the BRIP1/FANCJ gene predispose to breast cancer, we chose this gene as a...

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Identifiers

PMID: 19127258
DOI: 10.1038/sj.bjc.6604847
PMCID: PMC2634720

Genes

BRIP1
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A recurrent truncating germline mutation in the BRIP1/FANCJ gene and susceptibility to prostate cancer.PMID 19127258Read ↗

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Genetic and molecular analyses of candidate germline<i>BRIP1/FANCJ</i>variants implicated in breast and ovarian cancerSemantic proximity Read ↗

Mutational analysis of the breast cancer susceptibility gene BRIP1 /BACH1/FANCJ in high-risk non-BRCA1/BRCA2 breast cancer families.Semantic proximity Read ↗

Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles.Semantic proximity Read ↗

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Rare germline mutations in African American men diagnosed with early‐onset prostate cancerSemantic proximity Read ↗

The Genetic and Molecular Analyses of Rare Candidate Germline BRIP1/FANCJ Variants Implicated in Hereditary Breast and Ovarian Cancers.Semantic proximity Read ↗

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