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[Correlation of BRAF V600E Mutation with Clinical Features and Prognosis of Langerhans Cell Histiocytosis in Cildren].

Zhongguo shi yan xue ye xue za zhi - 1 Dec 2024

Li Xi, Xiao Li, Luo Ming-Zhu, Lei Xiao-Ying, Liu Hai-Yan, Yao Xin-Yuan, Guo Yu-Xia, Dou Ying, Yu Jie

Abstract excerpt

OBJECTIVE: To explore the gene mutations of Langerhans cell histiocytosis in children, and to analyze the correlation of BRAF V600E mutation with clinical features and prognosis of LCH, so as to provide reference for clinical diagnosis and treatment. METHODS: Fluorescence PCR was used to detect gene mutations in paraffin-embedded tissue samples from 78 children with LCH, and the correlation of BRAF V600E mutation...

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PMID: 39743286
DOI: 10.19746/j.cnki.issn.1009-2137.2024.06.043

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