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Article

Amino acid substitutions at the HIV-1 transframe region significantly impair virus infectivity.

PloS one - 1 Jan 2022

Yu Fu-Hsien, Huang Kuo-Jung, Wang Chin-Tien

Abstract excerpt

A transframe region within HIV-1 Gag-Pol (referred to as p6* or p6pol), directly linked to the protease (PR) N-terminus, plays a pivotal role in modulating PR activation. To identify specific p6* residues involved in PR activation, we created a series of p6* mutants by making substitutions for conserved p6* residues. Our results indicate that some p6* mutants were defective in terms of virus infectivity, despite...

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Identifiers

PMID: 35085286
DOI: 10.1371/journal.pone.0262477
PMCID: PMC8794111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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