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Article

Structure, biosynthetic origin, and engineered biosynthesis of calcium-dependent antibiotics from Streptomyces coelicolor.

Chemistry & biology - 1 Nov 2002

Hojati Zohreh, Milne Claire, Harvey Barbara, Gordon Lyndsey, Borg Matthew, Flett Fiona, Wilkinson Barrie, Sidebottom Philip J, Rudd Brian A M, Hayes Martin A, Smith Colin P, Micklefield Jason

Abstract excerpt

The calcium-dependent antibiotic (CDA), from Streptomyces coelicolor, is an acidic lipopeptide comprising an N-terminal 2,3-epoxyhexanoyl fatty acid side chain and several nonproteinogenic amino acid residues. S. coelicolor grown on solid media was shown to produce several previously uncharacterized peptides with C-terminal Z-dehydrotryptophan residues. The CDA biosynthetic gene cluster contains open reading...

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Identifiers

PMID: 12445768
DOI: 10.1016/s1074-5521(02)00252-1

Genes

CDA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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