Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phosphatase activity tunes two-component system sensor detection threshold.

Nature communications - 12 Apr 2018

Landry Brian P, Palanki Rohan, Dyulgyarov Nikola, Hartsough Lucas A, Tabor Jeffrey J

Abstract excerpt

Two-component systems (TCSs) are the largest family of multi-step signal transduction pathways in biology, and a major source of sensors for biotechnology. However, the input concentrations to which biosensors respond are often mismatched with application requirements. Here, we utilize a mathematical model to show that TCS detection thresholds increase with the phosphatase activity of the sensor histidine kinase....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aspartic Acid
Share to Biosensing Techniques
Share to Fertilizers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histidine Kinase

Share to Metabolic Engineering

Share to Nitrates

Share to Phosphoric Monoester Hydrolases

Source

Open in PubMed Open full text

Identifiers

PMID: 29650958
DOI: 10.1038/s41467-018-03929-y
PMCID: PMC5897336

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphatase activity tunes two-component system sensor detection threshold.PMID 29650958Read ↗

Disentangling the regulatory response of <i>Agrobacterium tumefaciens</i> CHLDO to glyphosate for engineering whole-cell phosphonate biosensorsSemantic proximity Read ↗

In Silico Design and Analysis of Genetic Circuit-Based Whole-Cell Biosensors for Detecting Groundwater ContaminantsSemantic proximity Read ↗

Dynamic and tunable metabolite control for robust minimal-equipment assessment of serum zinc.Semantic proximity Read ↗

The genetic architecture of an allosteric hormone receptor.Semantic proximity Read ↗

Artificial signaling in mammalian cells enabled by prokaryotic two-component system.Semantic proximity Read ↗

Stimuli−Expressed Protein Qubits for Quantum Quantification of Heavy Metals in Natural WaterSemantic proximity Read ↗

Transcription factor shielding yields a highly specific and sensitive whole-cell biosensor for Pb2+ detection.Semantic proximity Read ↗

Using Latent Chemical Recognition in an Evolved Periplasmic Binding Protein Family to Diversify BiosensorsSemantic proximity Read ↗

Design of a transcriptional biosensor for the portable, on-demand detection of cyanuric acidSemantic proximity Read ↗

Probing Mechanistic Similarities between Response Regulator Signaling Proteins and Haloacid Dehalogenase Phosphatases.Semantic proximity Read ↗

Development of Colorimetric-Based Whole-Cell Biosensor for Organophosphorus Compounds by Engineering Transcription Regulator DmpR.Semantic proximity Read ↗

Site-directed mutagenesis identifies a molecular switch involved in copper sensing by the histidine kinase CinS in Pseudomonas putida KT2440.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.