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Article

Probing Mechanistic Similarities between Response Regulator Signaling Proteins and Haloacid Dehalogenase Phosphatases.

Biochemistry - 9 Jun 2015

Immormino Robert M, Starbird Chrystal A, Silversmith Ruth E, Bourret Robert B

Abstract excerpt

Response regulator signaling proteins and phosphatases of the haloacid dehalogenase (HAD) superfamily share strikingly similar folds, active site geometries, and reaction chemistry. Proteins from both families catalyze the transfer of a phosphoryl group from a substrate to one of their own aspart...

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Identifiers

PMID: 25928369
DOI: 10.1021/acs.biochem.5b00286
PMCID: PMC4516285

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25928369-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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