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Transcription factor shielding yields a highly specific and sensitive whole-cell biosensor for Pb2+ detection.

Biosensors & bioelectronics - 15 Sept 2026

Shen Liang, Zhang Yubo, Su Junhan, Chen Yiwen, Lv Youxiang, Xiao Xiang, Xu An, Chen Shaopeng, Bao Lingzhi

Abstract excerpt

Whole-cell biosensors (WCBs) provide an economical and practical platform for the detection of environmental contaminants. However, their performance in complex samples is often compromised by limited specificity. In particular, sensing of lead ions (Pb2+) detection is frequently affected by interference from chemically similar metal ions such as mercury ions (Hg2+), resulting in non-specific signal responses. In...

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PMID: 42140064
DOI: 10.1016/j.bios.2026.118801

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