Dexamethasone-loaded glycyrrhiza protein nanoparticles reprogram macrophages to an anti-inflammatory phenotype via STAT6/IRF4 activation for alleviating sepsis-induced acute respiratory distress syndrome.

Abstract excerpt

Sepsis-induced acute respiratory distress syndrome (ARDS) is a life-threatening condition with uncontrolled inflammation and lung damage. Current therapies are limited, and reprogramming macrophages from pro-inflammatory M1 to anti-inflammatory M2 phenotypes via STAT6/IRF4 activation offers a promising strategy. Dexamethasone-loaded glycyrrhiza protein nanoparticles (Dex@GNPs) were synthesized by extracting GP,...

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• Anti-Inflammatory Agents
• Dexamethasone
• Interferon Regulatory Factors
• Macrophages
• Nanoparticles