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Article

The interaction of BDNF Val66Met, PTSD, and child abuse on psychophysiological reactivity and HPA axis function in a sample of Gulf War Veterans.

Journal of affective disorders - 1 Aug 2018

Young Dmitri A, Neylan Thomas C, O'Donovan Aoife, Metzler Thomas, Richards Anne, Ross Jessica A, Inslicht Sabra S

Abstract excerpt

INTRODUCTION: While the BDNF Val66Met polymorphism has been linked to various psychological disorders, limited focus has been on its relationship to posttraumatic stress disorder (PTSD) and early traumas such as child abuse. Therefore, we assessed whether Val66Met was associated with fear potentiated psychophysiological response and HPA axis dysfunction and whether PTSD status or child abuse history moderated...

Topics

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Adaptation, Psychological
Brain-Derived Neurotrophic Factor
Fear
Hydrocortisone
Hypothalamo-Hypophyseal System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pituitary-Adrenal System

Stress Disorders, Post-Traumatic

Source

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Identifiers

PMID: 29649711
DOI: 10.1016/j.jad.2018.04.004
PMCID: PMC6354935

Genes

BDNF
CAPS
DST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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