Article
The brain-derived neurotrophic factor Val66Met polymorphism predicts response to exposure therapy in posttraumatic stress disorder.
Biological psychiatry - 1 Jun 2013
Felmingham Kim L, Dobson-Stone Carol, Schofield Peter R, Quirk Gregory J, Bryant Richard A
Abstract excerpt
BACKGROUND: The most effective treatment for posttraumatic stress disorder (PTSD) is exposure therapy, which aims to facilitate extinction of conditioned fear. Recent evidence suggests that brain-derived neurotrophic factor (BDNF) facilitates extinction learning. This study assessed whether the Met-66 allele of BDNF, which results in lower activity-dependent secretion, predicts poor response to exposure therapy...
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