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Article

Functional Polymorphisms of the Type 1 and Type 2 Iodothyronine Deiodinase Genes in Autoimmune Thyroid Diseases.

Immunological investigations - 1 Jul 2018

Inoue Naoya, Watanabe Mikio, Katsumata Yuka, Ishido Naoko, Hidaka Yoh, Iwatani Yoshinori

Abstract excerpt

Graves' disease (GD) and Hashimoto's disease (HD) are major autoimmune thyroid diseases (AITDs), and their pathological conditions vary among patients. Type 1 iodothyronine deiodinase (D1) and type 2 iodothyronine deiodinase (D2) convert from thyroxine (T4) to triiodothyronine (T3). However, few findings have been described concerning the association between polymorphisms in D1 and D2 genes and AITD. Therefore,...

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PMID: 29648895
DOI: 10.1080/08820139.2018.1458861

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